JApan multicenter Mitral Annular Calcification mitral stenosis study

JRCT ID: jRCT1040240030

Registered date:23/05/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Mitral annular calcification related mitral stenosis
• Date of first enrollment: 23/05/2024
• Target sample size: 900
• Study type: Observational

Outcome(s)

• Primary Outcome: All-cause death

Secondary Outcome

Cardiac death, non cardiac death, hospitalization for heart failure, mitral valve intervention , cerebral infarction, infectious endcarditis, or a composite outcomes.
Change in mitral gradient, change in severity of mitral annular calcification,

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1. Age 18 years or older at baseline transthoracic echocardiography
2. Of patients who underwent transthoracic echocardiografy from January 2016 to December 2017, mitral gradiemt 5 or more mmHg and mitral annulus calcification were observed

Exclude criteria

1. patients with prior mitral valve surgery
2. patients with prior aotic valve replacement and valve dysfunction
3. patients who underwent transthoracic echocardiography within 24 hours after development of acute heart failure
4. patients with congenital heart diseases
5. patients who needed mechanical circulatory supports
6. patients who were not appropriate for this study based on the reserchers' decision
7. patients who reject the registration of this study as a result of the optout

Related Information

• Primary Sponsor: Okura Hiroyuki
• Secondary Sponsor: Kato Nahoko,JSPS KAKENHI Grant Number JP24997738