Detection of FFP of motor nerve origin by stimulating central nervous system

JRCT ID: jRCT1032230724

Registered date:20/03/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Not applicable
• Date of first enrollment: 20/03/2024
• Target sample size: 10
• Study type: Interventional

Intervention(s)

1. FFP Exploration via Peripheral Stimulation (Replication)
This study explores FFP detection by altering electrode positions during median nerve stimulation. Instead of traditional CMAP electrode placement, reference electrodes on the non-stimulated limb (e.g., radius or ulna) confirm FFP recording. Essential for comparative analysis, this method aligns with standard medical practices. Five subjects.
2. FFP Detection with Transcranial Stimulation
FFP recording, unachievable at standard CMAP sites due to TMS, is confirmed by placing reference electrodes on the non-stimulated limb. The study seeks optimal recording settings, measuring individual motor thresholds to set stimulation at 120% of this threshold, with intervals of at least 10 seconds, capping frequency at 0.1Hz. Five subjects.

Outcome(s)

• Primary Outcome: Far-field potentials
• Secondary Outcome: Conditions under which far-field potentials were measured (reference electrode position and frequency)

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both
• Include criteria: Healthy adults with no history of upper or lower limb fracture or surgery, cerebrovascular disease, epilepsy, cervical myelopathy, or depression that occurred within the past 6 months, no pacemaker or metal insertion.
• Exclude criteria: Individuals deemed inappropriate as subjects by the principal investigator (or sub-investigator)

Related Information

• Primary Sponsor: Hada Yasushi