Pre-administration of ephedrine and onset time of rocuronium action during induction of general anesthesia in elderly patients

JRCT ID: jRCT1031240496

Registered date:19/11/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Patients undergoing general anesthesia
• Date of first enrollment: 19/11/2024
• Target sample size: 30
• Study type: Interventional
• Intervention(s): Administer ephedrine or fresh food at the same time as induction of general anesthesia

Outcome(s)

• Primary Outcome: Onset time of rocuronium action with and without ephedrine during induction of general anesthesia

Secondary Outcome

Cardiac output before and after induction of anesthesia
Blood pressure before
and after induction of anesthesia Heart rate before and after induction of anesthesia

Key inclusion & exclusion criteria

• Age minimum: >= 80age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Patients 80 years of age or older undergoing general anesthesia
2) Patients with an American Society of Anesthesiologists pre-anesthesia risk rating of 3 or less
3) Patients with written consent for participation in this study

Exclude criteria

1) Patients who do not meet the above selection criteria
2) Patients with a history of allergy to muscle relaxants
3) Patients with severe systemic complications (American Society of Anesthesiologists pre-anesthetic risk rating of 4 or higher)
4) Obese patients with a BMI of 30 or greater and patients with a body mass index of less than 18.5
5) Patients with neuromuscular diseases
6) Patients with poorly controlled hypertension
7)Patients on beta blockers
8) Patients with a history of cardiovascular disease
9)Patients with moderate to severe hepatic dysfunction (Child-Pugh classification)
10)Patients with moderate to severe renal insufficiency
11) Patients with hyperthyroidism
12) Patients who have refused to participate in this study.

Related Information

• Primary Sponsor: Yamamoto Mai