A study of changes in urinary rocuronium concentration after continuous administration of rocuronium during hepatic blood flow interruption in liver resection surgery.

JRCT ID: jRCT1031230635

Registered date:15/02/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Patients undergoing hepatectomy
• Date of first enrollment: 15/02/2024
• Target sample size: 20
• Study type: Observational

Outcome(s)

• Primary Outcome: Urinary rocuronium concentration before and after hepatic blood flow blockade

Secondary Outcome

Plasma Rocuronium Concentration Before and After Hepatic Blood Blockade
Rocuronium protein binding before and after hepatic blood flow deprivation
Plasma bile acid concentration before and after hepatic blood flow deprivation

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Patients 20 years of age or older undergoing hepatectomy under general anesthesia
2) Cases with American Society of Anesthesiologists pre-anesthetic risk assessment 3 or less
3) Patients whose consent to participate in this study is obtained in writing.

Exclude criteria

1) Patients who do not meet the above selection criteria
2) Patients with a history of allergy to muscle relaxants
3) Patients with severe systemic complications (American Society of Anesthesiologists Preanesthetic Risk Rating 4 or higher)
4) Obese patients with a BMI of 30 or greater and patients with a body mass index of less than 18.5
5) Patients with neuromuscular diseases
6) Patients with moderate to severe hepatic dysfunction (Child-Pugh classification)
7) Patients who have refused to participate in this study.

Related Information

• Primary Sponsor: Yamamoto Mai