General anesthesia induction and intracranial pressure

JRCT ID: jRCT1031230607

Registered date:30/01/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Patients undergoing general anesthesia
• Date of first enrollment: 15/02/2024
• Target sample size: 46
• Study type: Interventional
• Intervention(s): The study is randomized between propofol and lemimazolam anesthesia.

Outcome(s)

• Primary Outcome: Intracranial Pressure
• Secondary Outcome: Cerebral blood flow, vaital sign, autonomic nerve activity, circulatory regulation.

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: <= 65age old
• Gender: Both

Include criteria

1. Healthy adult consented to participate in this study.
2. Patients with an American Society of Anesthesiologists pre-anesthesia risk rating of 2 or less
3. Patient who can be obtained cerebral blood flow velocity signal by transcranial Doppler ultrasonography.

Exclude criteria

1. Patients who refuse to participate in the study.
2. Patients who are deemed inappropriate as research subjects by the principal investigator.
3. Patients with a history of allergy to general anesthetic or food (dairy and soybean).
4. Patients with an American Society of Anesthesiologists pre-anesthesia risk rating of 3 or more.
5. Patients who have cerebrovascular disorder and an abnormal value of the intracranial pressure.
6. Patients undergoing an epidural or a peripheral nerve block with general anesthesia.

Related Information

• Primary Sponsor: Ogawa Yojiro