A comparative study of neuromuscular relaxant effects of remimazolam anesthesia in young and elderly patients.

JRCT ID: jRCT1031230514

Registered date:15/12/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Patients undergoing general anesthesia
• Date of first enrollment: 09/12/2023
• Target sample size: 40
• Study type: Interventional
• Intervention(s): Use remimazolam as a sedative. Blood samples are drawn during general anesthesia.

Outcome(s)

• Primary Outcome: PTC appearance time in the young and elderly groups

Secondary Outcome

T1 and T2 appearance time
Time until TOF ratio reaches 100% after sugammadex administration
PTC, blood rocuronium/remimazolam concentration at T1 and T2 appearance, and rocuronium protein binding rate

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: <= 91age old
• Gender: Both

Include criteria

1. Patients whose age is between 20 and 45 years old or between 70 and 91 years old
2. Patients with an American Society of Anesthesiologists pre-anesthesia risk rating of 3 or less
3. Patients who have given consent

Exclude criteria

1. Patients with a history of allergy to muscle relaxants or antagonists
2. Patients with severe complications
3. patients with neuromuscular disease
4. Patients taking medications that may affect the effect of muscle relaxation.
5. Patients who are deemed inappropriate as research subjects by the principal investigator
6. Patients who refuse to participate in the study.

Related Information

• Primary Sponsor: Takagi Shunichi
• Source(s) of Monetary Support: Grants-in-Aid for Scientific Research