Efficacy of intraoperative Nitrous Oxide use on postoperative pain in patients with cervical spinal cord injury

JRCT ID: jRCT1031210580

Registered date:25/01/2022

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Spinal cord injury
• Date of first enrollment: 25/01/2022
• Target sample size: 80
• Study type: Interventional
• Intervention(s): After the introduction of anesthesia, assigned to receive 60% nitrous oxide in 40% oxygen or Air-oxygen-sevoflurane during anaesthesia.

Outcome(s)

• Primary Outcome: Pain intensity:NRS for the past 24 hours before and after surgery

Secondary Outcome

1.Changes in the range of postoperative neuropathic pain:The range of pain/numbness along the upper limbs dermatome
2. Properties and intensity of neuropathic pain in the past 24 hours :NPSI
3. Psychological state:HADS
4. ADL:EQ5D
5. Degree of improvement:PGIC
6. Relationship between time to surgery and pain
7. Changes in pain for each ASIA classification

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both
• Include criteria: Patients aged 20 years or older with ASIA classification C or D cervical spinal cord injury who underwent urgent spinal surgery
• Exclude criteria: Pneumothorax , head injury, limb injury : fracture/nerve injury, non-speaking Japanese, impaired consciousness ,Complications of psychiatric disorders :such as suicidal ideation, complications of other trauma, history of blood disorders

Related Information

• Primary Sponsor: Sugimoto Mayu