Translational research:CARTiEr study

JRCT ID: jRCT1030240137

Registered date:03/06/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Ewing's sarcoma or solid tumors diagnosed as advanced relapsed with no standard treatment or refract
• Date of first enrollment: 03/06/2024
• Target sample size: 18
• Study type: Observational

Outcome(s)

Primary Outcome

Incidence of Secondary Cancer
Incidence of delayed toxicity

Secondary Outcome

Overall survival:OS
CAR gene copy number
CAR-positive cells number in peripheral blood
Phenotypic Analysis
TCR Repatoir Analysis
Plasma protein measurement
scRNA sequencing analysis
Immunostaining of tumor specimens
CAR gene expression analysis and immunostaining of secondary cancer specimens
Functional analysis of CAR-T cells

Key inclusion & exclusion criteria

• Age minimum: >= 18age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1.Patients enrolled in CARTiEr study
2.Written consent has been obtained from the patient for this ancillary study.

Exclude criteria

1.Written consent has not been obtained from the patient for this ancillary study.
2.Patients who are regarded as inappropriate for enrollment by investigators.

Related Information

• Primary Sponsor: Nakatsura Testuya
• Source(s) of Monetary Support: Japan Agency for Medical Research and Development