Plasma proteomic profiling in patients with atopic dermatitis following the administration of Nemolizumab

JRCT ID: jRCT1030230474

Registered date:22/11/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Atopic dermatitis
• Date of first enrollment: 22/11/2023
• Target sample size: 35
• Study type: Observational

Outcome(s)

• Primary Outcome: This study will perform explorative analysis of the temporal variations of each factor, using the pre-administration measurements of healthy adults and AD patients as controls. Based on these temporal variations, we will cluster the AD patients and perform pathway analysis for each cluster.

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: < 60age old
• Gender: Both

Include criteria

1) Group with AD patients
Stored plasma samples collected from AD patients with moderate or severe pruritus in the clinical trial (jRCT2080225290) will be used.

2)Group with healthy volunteers
Individuals who have never been diagnosed with AD in the past and are not currently diagnosed with AD
Individuals who can collect blood samples following a set procedure

Exclude criteria

Group with healthy volunteers
Individuals with a history of, or currently suffering from, severe diseases, including severe allergic diseases
Individuals who have administered medications containing immunomodulatory drugs (immunosuppressants, steroids or biological agents) within one month for topical drugs and within six months for oral or injectable drugs, counting from the blood collection date
Individuals who are currently undergoing treatment for a disease or who have received treatment within the past week
Individuals with a constitution such as atopic predisposition or allergy-prone
Individuals who have been advised to seek treatment or more serious intervention based on their most recent regular health check-up
Individuals who fall under the conditions listed in the 'Cases where you should refrain from donating' section on the Japanese Red Cross Society website
Individuals with a history of, or currently suffering from, drug or alcohol dependency
Individuals who are pregnant or currently breastfeeding
Individuals considered inappropriate for the study by the principal investigator of the clinical research

Related Information

• Primary Sponsor: Uratsuji Hideya