The development of exosome monitoring marker in pancreatic cancer

JRCT ID: jRCT1030230227

Registered date:14/07/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: pancreatic cancer, pancreatic benign disease (chronic pancreatitis, IPMN)
• Date of first enrollment: 13/10/2023
• Target sample size: 280
• Study type: Observational

Outcome(s)

• Primary Outcome: Difference in the amount of exosomes at the baseline among the pancreatic cancer, benign pancreatic disease and healthy control.

Secondary Outcome

1) Difference in the change in exosome levels before and after chemotherapy between the chemotherapy responsive and non-responsive groups.
2) Quantitative evaluation of the difference in exosome protein immunohistochemical staining (IHC) of FNA and surgical specimens between the chemotherapy responsive and non-responsive groups.
3) Difference in the exosome level compared at the baseline and at the reccurence.

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

(1) Individuals who was diagnosed with pancreatic cancer and untreated.
(2) Individuals who attend the hospital under the diagnosis of the benign pancreatic disease.
(3)Individuals who did not have a pancreatic cancer or the benign pancreatic tumor and visit Jikei medical chekup center.
(4) Individuals aged 20 and over.

Exclude criteria

(1) Individuals who declined to participate in the research.
(2) Individuals who are pregnant.

Related Information

• Primary Sponsor: Nana Shimamoto