Evaluation of microvasculr dysfunction in CTEPH

JRCT ID: jRCT1030220553

Registered date:29/12/2022

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: chronic thromboembolic pulmonary hypertension (CTEPH), chronic thromboembolic desease (CTED)
• Date of first enrollment: 29/12/2022
• Target sample size: 20
• Study type: Interventional
• Intervention(s): A pressure wire is used to measure the pulmonary microcirculatory indices based on the principle of thermodilution method. In addition to the ordinal therapeutic manipulation, 3 ml of saline injection into the local pulmonary artery is required. In addition, nitric oxide (NO) inhalation is required to examine pulmonary microvascular dilatation.

Outcome(s)

Primary Outcome

A pressure wire allows the measurement of mean transit time (Tmn) using the principle of thermodilution method. In addition, nitric oxide (NO) inhalation is used to induce hyperemia and assess pulmonary microvascular dilatation. Local pulmonary artery pressure and Tmn are used to calculate and assess the following pulmonary microcirculatory indices.

Vascular flow reserve (VFR) = Resting Tmn/Hyperemic Tmn
Index of microcirculatory resistance (IMR) = Distal pulmonary artery pressure/1/Resting Tmn
Resistive reserve ratio (RRR) = Resting IMR/Hyperemic IMR

Key inclusion & exclusion criteria

• Age minimum: >= 16age old
• Age maximum: Not applicable
• Gender: Both
• Include criteria: Patients with chronic thromboembolic pulmonary hypertension (CTEPH) or chronic thromboembolic desease (CTED) who underwent balloon pulmonary angioplasty (BPA) in our institution.
• Exclude criteria: None

Related Information

• Primary Sponsor: Sato Shuji