An exploratory intervention study of renal rehabilitation for patients with conservative chronic kidney disease

JRCT ID: jRCT1030220165

Registered date:25/06/2022

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: chronic kidney disease
• Date of first enrollment: 25/06/2022
• Target sample size: 12
• Study type: Interventional
• Intervention(s): Renal rehabilitation (exercise therapy, nutritional guidance)

Outcome(s)

• Primary Outcome: Change in urinary protein

Secondary Outcome

Change in 6-minute walk distance, cardiac function (left atrial strain)
Change in eGFR (Cre, Cys-C), presence of adverse events

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Age 20 or older at the time consent is obtained
2) Male or female resident in Japan
3) Inpatient or outpatient: outpatient
4) Patients who meet the criteria for chronic kidney disease
5) Urine protein level of 1 g/gCre or more for two consecutive urine tests at any time in an outpatient setting.
6) Independent in activities of daily living (ADL) (including walking with a cane)
7) Patients who can give written consent for participation of their own free will
8) Patients who understand and can perform the training on their own.

Exclude criteria

1) Patients who cannot give their consent
2) Patients on dialysis or renal transplant patients
3) Patients with eGFR (Cre) less than 8 or requiring dialysis induction within 3 months
4) Medically unstable patients (uncontrolled hypertension (blood pressure > 180/100 mmHg), congestive heart failure, active myocarditis/pericarditis, arrhythmia, etc.)
5) Patients with impaired mobility due to mental and physical problems
6) Patients who have participated in a structured exercise program within the past 6 months
7) Patients taking steroids
8) Patients who are deemed unsuitable as subjects by the principal investigator (subinvestigator)

Related Information

• Primary Sponsor: Aizawa Masashi