Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan

JRCT ID: jRCT1030220164

Registered date:25/06/2022

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Hepatitis A
• Date of first enrollment: 01/11/2018
• Target sample size: 1000
• Study type: Observational

Outcome(s)

• Primary Outcome: ALT, Anti-HCV, HBsAg, Anti-HBs, Anti-HAV, Anti-HEV, HAV RNA

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

Patients with acute hepatitis A who were admitted to Nihon University
School of Medicine Itabashi Hospital, Itabashi-ku, Tokyo, Japan between 1 January 2018
and 30 April 2020 were analyzed in the present study. Acute hepatitis A was diagnosed
by positive testing for immunoglobulin M (IgM) antibodies to HAV. All participants were
negative for the IgM anti-hepatitis B virus (HBV) core antibody, the anti-hepatitis C virus
(HCV) antibody, the IgA anti-hepatitis E virus (HEV) antibody, or for anti-HIV antibody.
This retrospective study was approved by the ethics committee of Nihon University School
of Medicine Itabashi Hospital (protocol no. RK-180911-12). Participation in the study was
posted at the website of our institution. This study conformed to the ethical guidelines of
the Declaration of Helsinki.

Exclude criteria

1) Patients do not want to enter the present study.
2) Patients who investigators judged as illegeble patients.

Related Information

• Primary Sponsor: Kanda Tatsuo
• Source(s) of Monetary Support: Japan Agency for Medical Research and Development (AMED) under Grant number JP20fk0210075