The study to identify the regions where AMPA receptors are highly expressed using [11C]K-2 images obtained from healthy subjects and patients with epilepsy

JRCT ID: jRCT1030210154

Registered date:17/06/2021

Basic Information

• Recruitment status: Not Recruiting
• Health condition(s) or Problem(s) studied: healthy subjects, patients with epilepsy
• Date of first enrollment: 17/06/2021
• Target sample size: 17
• Study type: Observational

Outcome(s)

Primary Outcome

1. Comparison of AMPA receptor density of healthy participants before and after partial volume correction.
2. Calculation of Asymmetry index of [11C]K-2 images before and after partial volume correction
3. Comparison of Asymmetry index of [11C]K-2 images Intra-individually and between healthy participants and epilepsy patients before and after partial volume correction.

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Both

Include criteria

-[11C] K-2 image data can be obtained from "A clinical trial to examine the efficacy and safety of radioligand [11C] K-2 in healthy subjects (UMIN000020975)" stored in the Department of Physiology, Yokohama City University.
-[11C] K-2 image data of healthy participants aged 30-40 yrs can be obtained from "A pilot study comparing the efficacy of radioligand [11C] K-2 in the development of cross-diseased diagnostics between depression, bipolar disorder, schizophrenia, addiction, ASD, epilepsy, FTD cases and healthy individuals Of the [11C] K-2 image data captured by (UMIN000025132)" stored in the Department of Physiology, Yokohama City University.
-[11C] K-2 image data of epilepsy patients showing significant reduction of seizures one year after surgery can be obtained from "a clinical trial investigating the efficacy of radioligand [11C] K-2 in patients undergoing anterior temporal lobe resection surgery for refractory epilepsy (UMIN000025090)", stored in the Department of Physiology, Yokohama City University.

Related Information

• Primary Sponsor: Miyazaki Tomoyuki