Effect of cream with tranexamic acid on post-inflammatory pigmentation after Q-switch ruby laser treatment

JRCT ID: jRCT1030200265

Registered date:24/12/2020

Basic Information

• Recruitment status: Complete
• Health condition(s) or Problem(s) studied: Senile lentigine
• Date of first enrollment: 24/12/2020
• Target sample size: 45
• Study type: Other
• Intervention(s): After one month of pretreatment, we will treat the spots with a Q-switched ruby laser.

Outcome(s)

• Primary Outcome: Rate of incidence of post-inflammatory pigmentation one month after laser treatment
• Secondary Outcome: Rate of incidence of post-inflammatory pigmentation pre and post-laser treatment

Key inclusion & exclusion criteria

• Age minimum: >= 20age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1) Japanese and over 20
2) Senile pigmented spots on the face
3) According to the doctor's instructions, you can continue to use the research item twice daily.
4) Agree with regular visits

Exclude criteria

1) Received beauty (whitening) treatment within the last 3 months
2) Used whitening cosmetics within the last 3 months
3) In the past, external use of tranexamic acid caused dermatitis
4) Experienced dermatitis due to hair dye
5) Vitiligo
6) History of Vitiligo
7) Precancerous lesion, malignant tumor, or suspected
8) Hemorrhagic disease
9) Melasma
10) Taking a drug that has high photosensitivity or enhances photosensitivity.
11) History of rheumatism and history of oral administration of gold preparation
12) There is a gold thread in the laser irradiation area
13) There is a skin-colored/white tattoo on the laser-irradiated area.
14) Pregnant and possibly pregnant
15) Lactating
16) In addition the doctor determined that it was inappropriate

Related Information

• Primary Sponsor: Bunsho Kao