Effect of remimazolam compared to propofol on blood pressure variability in the elderly

JRCT ID: jRCT1011230012

Registered date:21/06/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Hypotension during general anesthesia induction
• Date of first enrollment: 21/06/2023
• Target sample size: 20
• Study type: Interventional

Intervention(s)

Group A: At the time of general anesthesia induction, remimazolam is administered at 12 mg/kg/h until unconsciousness.
Group B: At the time of general anesthesia induction, propofol is administered at 0.5 mg/kg/10 sec until unconsciousness.

Outcome(s)

• Primary Outcome: The maximum change in mean blood pressure during general anesthesia induction
• Secondary Outcome: The percentage of mean blood pressure <60 mmHg during general anesthesia induction, The maximum change in heart rate during general anesthesia induction, The percentage of heart rate <45 bpm during general anesthesia induction

Key inclusion & exclusion criteria

• Age minimum: >= 70age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

1. ASA P.S. 1 or 2
2. Written informed consent

Exclude criteria

1. Acute angle closure glaucoma
2. Myasthenia gravis
3. Allergy to propofol
4. Allergy to remimazolam
5. Revised Cardiac Risk Index >0
6. Sleep apnea syndrome
7. BMI greater than 35
8. Previous thoracoplasty
9. Previous pneumonectomy

Related Information

• Primary Sponsor: Hojo Takayuki
• Source(s) of Monetary Support: Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan (22K10139)