Measurement of the concentration of free remimazolam

JRCT ID: jRCT1011230004

Registered date:29/04/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Cardiocascular surgery
• Date of first enrollment: 29/04/2023
• Target sample size: 5
• Study type: Observational

Outcome(s)

• Primary Outcome: Concentration of free remimazolam

Secondary Outcome

Concentration of total remimazolam, a metabolite of remimazolam (CNS7054), and albumin
Protein binding ratio of remimazolam

Key inclusion & exclusion criteria

• Age minimum: >= 201age old
• Age maximum: Not applicable
• Gender: Both

Include criteria

Equal to or older than 20 years old
Patients who receive cardiovascular surgery under cardiopulmonary bypass with remimazolam

Exclude criteria

Refusal to participate
Emergent case
Allergy against remimazolam
Acute angle closure glaucoma
Myasthenia gravis
Hepatic failure (Child Pugh equal to or more than 2)
Renal failure (sCre equal to or more than 2 mg/dL)
Obesity (BMI equal to or more than 35 kg/m2)
Deep hypothermic circulatory arrest
Patients who are considered to be inappropriate to participate to the study

Related Information

• Primary Sponsor: Yoshikawa Yusuke