Efficacy test of study to examine the adsorption and penetration of zinc into keratin plugs by continuous use of zinc oxide preparations

UMIN ID: UMIN000056560

Registered date:06/01/2025

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Not applicable
• Date of first enrollment: 2025/01/06
• Target sample size: 20
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Apply product with ZnO to the face twice a day for 1wks.

Outcome(s)

• Primary Outcome: Evaluation of the amount of zinc adsorbed onto the surface of keratin plugs and the degree of zinc penetration into the keratin plugs after one week of continuous use of the preparation

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 59years-old
• Gender: Male and Female
• Exclude criteria: 1.Those who are pregnant or may be pregnant, breastfeeding, or less than 6 months postpartum 2.Those who have participated in other studies (all studies using cosmetics, food, pharmaceuticals, quasi-drugs, medical devices, etc.) within the past 4 weeks, or those who have participated in other human studies during the scheduled implementation period of this study. Those who are planning to participate. 3.Those with skin symptoms such as atopic dermatitis or contact dermatitis. 4.Those with a history of allergies or rashes to cosmetics, adhesive tapes, medical tapes, etc. 5.Those with facial skin abnormalities (rash, eczema, wounds, bruises, etc.). 6.Those who have had severe sunburn on their face within the past month 7.Those who are visiting a medical institution due to poor physical condition or skin disease. 8.Those using cosmetics, quasi-drugs, or pharmaceuticals that may affect the test (peels, steroids, anti-inflammatory drugs, topical drugs, antibacterial drugs, etc.). 9.Those with seasonal allergies such as severe hay fever. 10.Those who have received cosmetic treatment for the face (laser treatment, collagen injection, etc.). 11.Those who have had aesthetic treatment on their face within the past month 12.Those who use home facial beauty devices or beauty equipment 13.Those who have a habit of smoking. 14.Those who are deemed unsuitable for research participation by the research director due to violation of compliance obligations, etc.

Related Information

• Primary Sponsor: Kao Corporation
• Source(s) of Monetary Support: Kao Corporation