UMIN ID: UMIN000056205
Registered date:20/11/2024
Efficacy and Safety of Early Neuromuscular Blocking Agent Therapy in Patients with Moderate to Severe ARDS: A Systematic Review
Basic Information
| Recruitment status | Pending |
|---|---|
| Health condition(s) or Problem(s) studied | Acute Respiratory Distress Syndrome (ARDS) |
| Date of first enrollment | 2024/11/19 |
| Target sample size | |
| Countries of recruitment | Japan |
| Study type | Others,meta-analysis etc |
| Intervention(s) |
Outcome(s)
| Primary Outcome | To evaluate the efficacy of early neuromuscular blockade in reducing mortality among patients with moderate to severe ARDS, initiated within 48 hours of diagnosis. |
|---|---|
| Secondary Outcome | To determine whether the use of neuromuscular blocking agents in patients with moderate or severe ARDS, initiated within 48 hours of diagnosis, improves the quality of life (QOL) as measured by EQ-5D, reduces the incidence of pressure injuries, shortens the duration of mechanical ventilation, and decreases the occurrence of ICU-acquired weakness. A subgroup analysis will compare studies where the control group received deep sedation versus light sedation. |
Key inclusion & exclusion criteria
| Age minimum | Not applicable |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Patients with a history of neuromuscular blocking agent use within the past 2 weeks. Patients with chronic respiratory failure. |
Related Information
| Primary Sponsor | Fukuyama City Hospital |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Fukuyama City Hospital |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Kenzo Ishii |
| Address | 5-23-1 Zao-cho, Fukuyama, Hiroshima, Japan Japan 721-8511 |
| Telephone | 0849415151 |
| keishii1101@gmail.com | |
| Affiliation | Fukuyama City Hospital Department of Anesthesiology, Intensive Care Unit |
| scientific contact | |
| Name | Kenzo Ishii |
| Address | 5-23-1 Zao-cho, Fukuyama, Hiroshima, Japan Japan |
| Telephone | 084-951-5151 |
| keishii1101@gmail.com | |
| Affiliation | Fukuyama City Hospital Department of Anesthesiology, Intensive Care Unit |