Effects of long-term glutamine supplementation on athlete's immunity, inflammation, and oxidative stress

UMIN ID: UMIN000056143

Registered date:13/11/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: healthy individuals
• Date of first enrollment: 2024/11/07
• Target sample size: 20
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Participants will consume L-glutamine or placebo at a dose of 0.3 g/kg/day for 8 weeks, followed by a 4-week washout period, in a crossover trial lasting a total of 20 weeks.
Participants will consume L-glutamine or placebo at a dose of 0.3 g/kg/day for 8 weeks, followed by a 4-week washout period, in a crossover trial lasting a total of 20 weeks.

Outcome(s)

• Primary Outcome: immune, inflammation, oxidative stress markers / gut microbiome
• Secondary Outcome: VO2max

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: 29years-old
• Gender: Male and Female
• Exclude criteria: 1. Abnormal findings on resting 12-lead electrocardiogram and/or blood pressure, Cannot limit drinking alcohol the day before the experiment, Smoking or taking antioxidant supplements, Taking anti-allergy agent or anti-inflammatory agent 2. Unable to participate in competitions or training due to injuries

Related Information

• Primary Sponsor: Waseda University
• Source(s) of Monetary Support: Waseda University
• Secondary ID(s): 2024-342