Bactericidal effect of toothpaste containing silver ion against oral pathogens

UMIN ID: UMIN000056101

Registered date:10/12/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Dental caries, chronic periodontitis, oral candidiasis, opportunistic infections caused by staphylococci
• Date of first enrollment: 2024/12/20
• Target sample size: 100
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Participants will be instructed to use a commercially available silver ion toothpaste (SMILE YOU) freely during their regular brushing routine for a continuous period of 180 days.
Participants will be instructed to use a commercially available silver ion toothpaste (SMILE ONE) freely during their regular brushing routine for a continuous period of 180 days.

Outcome(s)

• Primary Outcome: Subjects will be randomly assigned to either a group using two toothpastes containing silver ions or a group using a toothpaste without silver ions. To evaluate the bactericidal effect of silver ions, the proportions of various oral pathogens in saliva will be assessed through culture testing on selective media before toothpaste use and at 30, 90, and 180 days after starting use.

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: Minors, pregnant women, those who have received antimicrobial agents within the past 6 months, those with systemic diseases, and those with xerostomia.

Related Information

• Primary Sponsor: Nihon University
• Source(s) of Monetary Support: Pikasshu corporation