Investigation of cerebral blood flow changes in patients with orthostatic hypotension

UMIN ID: UMIN000056074

Registered date:10/11/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Patients with neurological disorders that may cause autonomic neuropathy Examples: Parkinson's disease, dementia with Lewy bodies, pure autonomic failure, multiple system atrophy, corticobasal ganglia degeneration, progressive supranuclear palsy, spinocerebellar degeneration, familial amyloid polyneuropathy, autoimmune autonomic ganglionopathy, diabetic neuropathy, Sjogren's syndrome, paraneoplastic neurologic syndromes, autoimmune CNS inflammatory diseases, vasculitis syndromes
• Date of first enrollment: 2024/11/10
• Target sample size: 50
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Cerebral blood flow is measured by near-infrared spectroscopy using HOT-2000 manufactured by NeU.

Outcome(s)

• Primary Outcome: concentration of oxygenated hemoglobin
• Secondary Outcome: Serum BDNF, serum GFAP, serum UCH-L1, serum NfL, MMSE, FAB

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: Pregnant or at risk of pregnancy. Patients with stroke or with a history of stroke. Patients with neuroendocrine tumor. Patients who are not able to cross their legs, push, hold a standing position, and walk. Patients who are judged by the investigator to be inappropriate to participate in this study.

Related Information

• Primary Sponsor: Hamamatsu University School of Medicine
• Source(s) of Monetary Support: Hamamatsu University School of Medicine department of neurology