Influence of ovarian hormones on inflammatory responses and indirect markers of muscle injury following exercise-induced muscle damage

UMIN ID: UMIN000056015

Registered date:01/11/2024

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Exercise-induced muscle damage
• Date of first enrollment: 2022/04/07
• Target sample size: 36
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Eccentric exercise using non-dominant arms 10 sets of maximal voluntary isokinetic eccentric exercises elbow flexors at a velocity of 90 degree/s for ROM from 90 degree-0 degree flexion, indicating a full extension (rest for 2 min between sets)
Eccentric exercise using non-dominant arms 10 sets of maximal voluntary isokinetic eccentric exercises elbow flexors at a velocity of 90 degree/s for ROM from 90 degree-0 degree flexion, indicating a full extension (rest for 2 min between sets)

Outcome(s)

• Primary Outcome: Blood samples are collected at pre- and 4,48 and 96 h postexercise to analyze estradiol and progesterone concentrations, leukocyte count and fractionation, interleukin-6, and creatine kinase activity. Also assess the maximal voluntary isometric contraction torque of elbow flexion, range of motion in elbow joint, upper-arm circumference, and muscle soreness as indirect muscle damage markers at pre-; immediately post; and 4,48,96 h postexercise.

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 40years-old
• Gender: Male and Female
• Exclude criteria: who do not comply with the inclusion criteria

Related Information

• Primary Sponsor: Teikyo University of Science
• Source(s) of Monetary Support: Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research(C)