Low-density lipoprotein cholesterol associated with change in non-culprit plaque lipid burden of acute coronary syndrome

UMIN ID: UMIN000055586

Registered date:30/09/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: acute coronary syndrome
• Date of first enrollment: 2023/12/01
• Target sample size: 100
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: In ACS patients who reduced LDL-C to less than 55 mg/dL compared to those who reduced it to between 55 and 70 mg/dL, we will evaluate how the plaques with maxLCBI4mm > 400 and < 400 in non-culprit lesions changed as assessed by NIRS-IVUS. Additionally, we will examine whether there are any changes in lipid markers other than LDL-C in these patients.

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 90years-old
• Gender: Male and Female
• Exclude criteria: (1) chronic kidney disease as shown by an estimated glomerular filtration rate <30 ml/min/1.73 m2; (2) presentation with hemodynamic instability; (3) severe valvular heart diseases, (4) left main trunk lesions; (5) lesions that could not be evaluated by NIRS-IVUS for any reason (e.g., tortuous vessels, severe stenosis, and calcification that made catheter passage difficult); and (6) poor image quality that resulted in an inability to perform CCTA or NIRS-IVUS analysis.

Related Information

• Primary Sponsor: Kindai University Faculty of Medicine
• Source(s) of Monetary Support: Kindai University Faculty of Medicine