UMIN ID: UMIN000055555
Registered date:20/09/2024
Evaluation of a Novel PET Imaging Method for Assessing Liver Cancer Treatment Response
Basic Information
| Recruitment status | Recruiting |
|---|---|
| Health condition(s) or Problem(s) studied | hepatocellular carcinoma |
| Date of first enrollment | 2024/09/20 |
| Target sample size | 20 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | The intervention in this study is PET/CT imaging using ^18^F-FAPI-74. This imaging technique is performed on patients with hepatocellular carcinoma before and after systemic drug therapy. Specifically, the radioactive tracer ^18^F-FAPI-74 is administered intravenously, followed by whole-body imaging using a PET/CT scanner. The intervention is conducted in a single group, with each patient undergoing the same procedure twice - once before treatment and once after treatment. |
Outcome(s)
| Primary Outcome | Correlation between the rate of change in 18F-FAPI-74 PET quantitative values for each lesion and treatment response assessment by RECIST and mRECIST criteria |
|---|---|
| Secondary Outcome | 1. Correlation between the rate of change in 18F-FAPI-74 PET quantitative values and the rate of change in tumor markers (AFP, PIVKA-II) 2. Comparison of pre-treatment 18F-FAPI-74 PET/CT imaging findings with those of contrast-enhanced CT and MRI |
Key inclusion & exclusion criteria
| Age minimum | 18years-old |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Pregnant women or those who may be pregnant Individuals with severe claustrophobia Individuals deemed unsuitable for participation in this study by the principal investigator or co-investigators |
Related Information
| Primary Sponsor | Kobe City Medical Center General Hospital |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Kobe City Medical Center General Hospital |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Shojiro Oka |
| Address | 2-1-1 Minatojima Minamimachi, Chuo-ku, Kobe City, Hyogo Prefecture, Japan Japan 6500047 |
| Telephone | 0783024321 |
| shojiro511@gmail.com | |
| Affiliation | Kobe City Medical Center General Hospital Department of Diagnostic Radiology |
| scientific contact | |
| Name | Tomohiko Yamane |
| Address | 2-1-1 Minatojima Minamimachi, Chuo-ku, Kobe City, Hyogo Prefecture, Japan Japan |
| Telephone | 0783024321 |
| tomohiko_yamane@kcho.jp | |
| Affiliation | Kobe City Medical Center General Hospital Department of Molecular Imaging Research |