The effect of chemical mouthwash on halitosis and oral microbiome in orthodontic patients.

UMIN ID: UMIN000055502

Registered date:17/09/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: malocclusion
• Date of first enrollment: 2025/01/20
• Target sample size: 32
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

1.The test group uses Mondamin HABITPRO (Earth Chemical, Tokyo, Japan) three times a day (10 ml, 20 seconds, 14 days (2 weeks), morning, noon and evening mouthwash after brushing). 2.Participants are instructed to maintain normal oral hygiene habits for the duration of the study.
1.The control group uses a placebo mouthwash made by Earth Chemical (Tokyo, Japan)three times a day (10 ml, 20 seconds, 14 days (2 weeks), morning, noon and evening mouthwash after brushing). 2.Participants are instructed to maintain normal oral hygiene habits for the duration of the study.

Outcome(s)

• Primary Outcome: Hydrogen sulfide (H2S), Methyl-mercaptan (CH3SH), Dimethyl sulfide ([(CH3)2S])

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: 40years-old
• Gender: Male and Female
• Exclude criteria: Patients with active caries, periodontitis (periodontal pockets 3 mm or more), dental fluorosis/ dysplasia of the teeth, syndromes or other abnormalities of the craniofacial complex, mental problems, subjects smoking or using other tobacco products, taking antibiotics during the last 2 months, use of chlorhexidine or another mouthwash in the last 3 weeks, allergy to cetylpyridinium chloride, and participating in other trials are excluded.

Related Information

• Primary Sponsor: Tsurumi University
• Source(s) of Monetary Support: Tsurumi University