Effects of Anesthetic Drugs and Head Position Changes on Cerebral Tissue Oxygen Saturation in General Anesthesia.

UMIN ID: UMIN000054972

Registered date:16/07/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Men and women over 20 years old scheduled for oral surgery under general anesthesia at Kanagawa Dental University Hospital.
• Date of first enrollment: 2024/08/01
• Target sample size: 20
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Use of inhaled anesthetic agents in the maintenance of general anesthesia.
Use of Propofol in the maintenance of general anesthesia.
Use of Remimazolam in the maintenance of general anesthesia.

Outcome(s)

• Primary Outcome: The rate of change in Tissue Oxygen Index. In situations where near-infrared spectroscopy is used on brain tissue, tissue oxygen index and brain tissue oxygen saturation are synonymous.

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1. an ASA-PS of 3 or higher 2. blood samples taken prior to the preoperative visit that meet the following criteria AST (GOT) or ALT (GPT) greater than 100 IU/L Serum creatinine > 2.0 mg/dL HbA1c greater than or equal to 7.5 3. taking benzodiazepines for more than 1 year 4. whose EEG and BIS values may not be properly measured (including vascular lesions) 5. those with a cardiac pacemaker or ICD 6. who have expressed (including verbally) their refusal to participate in this study 7. other subjects deemed inappropriate by the principal investigator

Related Information

• Primary Sponsor: Kanagawa Dental University
• Source(s) of Monetary Support: Self funding