Measurement of Changes in GABA Concentration in the Human Brain Following Rosmarinic Acid Administration Using Magnetic Resonance Spectroscopy

UMIN ID: UMIN000054669

Registered date:15/06/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Healthy volunteers
• Date of first enrollment: 2024/06/15
• Target sample size: 10
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Administration of a rosmarinic acid-containing supplement and MRI imaging

Outcome(s)

• Primary Outcome: Changes in brain GABA concentration before and after administration of a rosmarinic acid-containing supplement, measured by MRS imaging.

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: 45years-old
• Gender: Male and Female
• Exclude criteria: 1.Diagnosed with a mental disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM-5-TR) 2.Pregnant or breastfeeding women 3.History of physical dysfunction such as liver, kidney, or heart issues 4.Allergies to herbs, supplements, or polyphenols 5.Smokers 6.Currently taking medication 7.Having an implanted metal device such as a pacemaker (for safety reasons) 8.Head, neck, or body size not suitable for the MRI scanner (for safety reasons) 9.Having a tattoo larger than a one-point size, including tattoos and permanent makeup (for safety reasons) 10.Severe claustrophobia (for safety reasons)

Related Information

• Primary Sponsor: Department of Neuropsychiatry, Keio University School of Medicine
• Source(s) of Monetary Support: Inokashira Hospital Foundation