Comparison of Multimodal Cocktail Periarticular Injection and Peripheral Nerve Block in Pain Relief After Osteotomy Around the Knee: A Prospective Randomized Controlled Trial

UMIN ID: UMIN000054638

Registered date:13/06/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: knee osteoarthritis
• Date of first enrollment: 2024/06/21
• Target sample size: 120
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Percutaneous periarticular analgesic injection including ropivacaine 0.75% 40 mL, ketoprofen 2.5 mL [50 mg], and methylprednisolone sodium succinate 0.8 mL [50 mg] just before osteotomy around the knee.
A total of 20 mL of 5 mg/mL of ropivacaine was injected around the sciatic nerve and a total of 15 mL of 3.3 mg/mL of ropivacaine was injected around the femoral nerve just before

Outcome(s)

• Primary Outcome: Visual Analogue Scale for postoperative pain at rest measured at 4, 8, 16, and 24 hours after surgery.
• Secondary Outcome: Complication Visual Analogue Scale during activity (measured at one to five days after surgery)

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 80years-old
• Gender: Male and Female
• Exclude criteria: not meeting inclusion criteria poorly controlled diabetes mellitus declined to participate

Related Information

• Primary Sponsor: Hyogo Medical University
• Source(s) of Monetary Support: Hyogo Medical University