NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000054590

Registered date:10/06/2024

Investigation of factors affecting the in vivo degradation of the intravenous anesthetic remimazolam.

Basic Information

Recruitment status Recruiting
Health condition(s) or Problem(s) studiedDental and Oral Surgical Diseases
Date of first enrollment2024/06/10
Target sample size40
Countries of recruitmentJapan
Study typeObservational
Intervention(s)

Outcome(s)

Primary OutcomeRemimazolam blood concentration at various time points after completion of remimazolam administration
Secondary Outcome- Patient information: age, weight, height, BMI, gender, medical history, medications, and laboratory test results - Surgical information: operation details, operation time, anesthesia time - Time from the end of remimazolam administration to extubation (awake time) - Blood concentration of CNS7054 at each time point after completion of remimazolam administration - Pharmacokinetic parameters such as AUC (area under the blood concentration-time curve) of remimazolam and CNS7054 - BIS values at the end of remimazolam and at the time of extubation or flumazenil administration - Remimazolam total dose, average rate of administration - Remifentanil total dose, mean rate of administration - BIS values before anesthetic administration, during loss of consciousness, and during maintenance of anesthesia - Time from remimazolam administration to loss of consciousness - Number of bolus doses of remimazolam

Key inclusion & exclusion criteria

Age minimum18years-old
Age maximum50years-old
GenderMale and Female
Include criteria
Exclude criteria1. Patients with contraindications to remimazolam, remifentanil, or rocuronium 2. Patients requiring preanesthetic medication 3. Other patients deemed inappropriate for participation in the study by the principal investigator and research coordinators.

Related Information

Contact

public contact
Name Hitoshi Higuchi
Address 2-5-1 Shikata-cho Kita-ku, Okayama Japan 700-8252
Telephone 086-235-6721
E-mail higuti@md.okayama-u.ac.jp
Affiliation Okayama University Hospital Department of Dental Anesthesiology
scientific contact
Name Hitoshi Higuchi
Address 2-5-1 Shikata-cho Kita-ku, Okayama Japan
Telephone 086-235-6721
E-mail higuti@md.okayama-u.ac.jp
Affiliation Okayama University Hospital Department of Dental Anesthesiology