Phase II study of stereotactic MR-guided online adaptive radiosurgery for small lung cancer

UMIN ID: UMIN000054375

Registered date:01/06/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: primary lung cancer, metastatic lung cancer
• Date of first enrollment: 2024/06/01
• Target sample size: 25
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): To perform stereotactic MR-guided online adaptive radiosurgery for small lung cancer

Outcome(s)

• Primary Outcome: One-year local control and incidences of rib fracture
• Secondary Outcome: One-year overall survival time One-year progression free survival Incidences of serious adverse events

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1.Patients with severe complications such as uncontrolled diabetes, collagen disease, heart disease, lung disease, kidney disease, and mental illness 2.Receiving home oxygen therapy 3.Pregnant, lactating, or likelihood of pregnancy 4.Active infectious disease 5.History of radiation therapy that may overlap with the current treatment 6.Presence of obvious interstitial shadows on CT images 7.Cases with pacemakers, implanted defibrillators, or other internal metals incompatible with MRI 8.Claustrophobia preventing MRI examination 9.Patients with psychiatric illness or symptoms making participation in the study difficult to assess

Related Information

• Primary Sponsor: Tohoku University Hospital
• Source(s) of Monetary Support: Japan Science and Technology Agency