Association between delivery type and Kawasaki disease onset

UMIN ID: UMIN000054284

Registered date:30/04/2024

Basic Information

• Recruitment status: Complete: follow-up continuing
• Health condition(s) or Problem(s) studied: Kawasaki disease
• Date of first enrollment: 2005/01/01
• Target sample size: 70000
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: Patients with KD were identified from the source population. Subsequently, in every case, we randomly selected controls with no KD history based on a risk-set sampling technique. Each patient was matched to four controls of the same sex, age, and registration time in the database. We subsequently examined the association between the delivery type and KD onset using multivariate conditional logistic regression analysis.We defined the primary outcome as KD, based on specific criteria.

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: 7years-old
• Gender: Male and Female
• Exclude criteria: Cases labeled as suspected were excluded, whereas those with atypical KD were included. Considering the importance of an accurate diagnosis in this study, we excluded patients more than 6 years of age because this is not the typical age of KD onset, and distinguishing KD from other diseases in this age group is challenging.

Related Information

• Primary Sponsor: Chiba Cancer Center Research Institute
• Source(s) of Monetary Support: Chiba Cancer Center Research Institute