Search for an optimal equation for estimating glomerular filtration rate (GFR) in Japanese patients with digestive malignancies: Considering muscle mass

UMIN ID: UMIN000054261

Registered date:30/04/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: unresectable digestive malignancies
• Date of first enrollment: 2024/01/16
• Target sample size: 100
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: Correlation between inulin clearance and eGFR calculated using various estimation equations
• Secondary Outcome: Clinical characteristics of cases with significant discrepancies between inulin clearance and eCcr calculated by the CG equation

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: 1. History of hypersensitivity to inulin. 2. Those who are taking probucol, tocopherol acetate, or vitamin preparations and are unable to take a break from taking them on the day before and on the day of inulin clearance measurement. 3. The patient is taking methyldopa orally. 4. eGFR calculated using the Japanese Society of Nephrology's estimation formula is less than 15 mL/min/1.73m2. 5. Subjects who are taking steroids and cannot stop taking them for 14 days before measuring inulin clearance. 6. Other individuals who are judged by the research director or co-researcher to be inappropriate as research subjects.

Related Information

• Primary Sponsor: Hokkaido university hospital
• Source(s) of Monetary Support: Hokkaido university hospital, Hokkaido Gastrointestinal Cancer Study Group(HGCSG)