Effects and mechanism of mTOR-mediated autophagy induced by different exercise prescriptions in sarcopenia

UMIN ID: UMIN000054193

Registered date:18/04/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Open public recruiting
• Date of first enrollment: 2024/05/01
• Target sample size: 210
• Countries of recruitment: Asia(except Japan)
• Study type: Interventional

Intervention(s)

Low-intensity aerobic exercise group: Starting with a power bicycle, and subsequently allowing subjects to choose aerobic exercise training equipment according to their personal preferences, such as a treadmill, elliptical trainer, or a four-limb linkage trainer, with each session aiming to burn 150 kcal. The low-intensity aerobic exercise group engages in activities at 50-55% of their peak oxygen uptake rate.
High-intensity aerobic exercise group: Starting with a power bicycle, and then allowing subjects to choose from a treadmill, elliptical machine, or a four-limb linkage trainer based on their personal preferences for aerobic exercise training equipment, with each session designed to expend 150 kcal. The high-intensity aerobic exercise group performs at 70-75% of their peak oxygen uptake.
Resistance exercise group: Six types of weightlifting exercises for both upper and lower body parts, where subjects can choose two types of equipment for the upper body and two for the lower body based on their preference for strength training. The resistance is set at 60-70% of the subject's one-repetition maximum for each exercise movement. Each set consists of 8 repetitions, followed by 2 sets per movement. After completing one set, there is a rest period of 2-3 minutes before proceeding to the next exercise.
Control group: no exercise intervention

Outcome(s)

• Primary Outcome: The primary outcome measures of this study include muscle mass, muscle strength, 4-meter walking speed, and the longitudinal changes in mTOR and autophagy assessed at four time points.
• Secondary Outcome: Blood indicators, Timed Up and Go Test (TUGT), Short Physical Performance Battery (SPPB), 6-minute walk distance, dietary nutrition and sleep status, physical activity levels, and changes in maximal oxygen uptake.

Key inclusion & exclusion criteria

• Age minimum: 60years-old
• Age maximum: 100years-old
• Gender: Male and Female
• Exclude criteria: Patients with conditions affecting muscles and bones, such as renal failure, cancer, stroke, severe liver disease, diabetes, thyroid or parathyroid disorders; on medications like glucocorticoids, sex hormones, thyroid hormones; with severe heart conditions, cognitive or psychiatric impairments, cancer, joint contractures, metal implants, or severe disabilities; had recent major surgeries or refuse to consent to the study management are excluded.

Related Information

• Primary Sponsor: Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences
• Source(s) of Monetary Support: Non