Evaluation of qualitative imaging techniques after autologous cultured chondrocyte implantation

UMIN ID: UMIN000054185

Registered date:01/05/2024

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: cartilage injury of knee joint
• Date of first enrollment: 2024/05/01
• Target sample size: 30
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Qualitative MRI will be performed on patients who have undergone autologous cultured chondrocyte transplantation for knee cartilage injury after 0-20 years between March 2017 and September 2019. T1rho map and T2 map will be measured from the obtained images. Morphological MRI images are taken under the same conditions.The MOCART score is calculated from the obtained images. Clinical scores (Lysholm score, KOOS score, IKDC score, WOMAC score) are calculated under the same conditions.

Outcome(s)

• Primary Outcome: Postoperative time correlates with T1rho map and T2map values on qualitative MRI examination, qualitative MRI can detect the condition of transplanted tissue 0 to 20 years after autologous cultured chondrocyte implantation.
• Secondary Outcome: Morphological MRI images and MOCART score Clinical scores VAS, koos score, Lysholm score, WOMAC

Key inclusion & exclusion criteria

• Age minimum: 15years-old
• Age maximum: 70years-old
• Gender: Male and Female
• Exclude criteria: Imaging tests with qualitative measurements could not be performed or the data were poor.

Related Information

• Primary Sponsor: Shimane University
• Source(s) of Monetary Support: Shimane University