Computed Tomography Perfusion Tissue Time to Maximum Predict Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage

UMIN ID: UMIN000054121

Registered date:11/04/2024

Basic Information

• Recruitment status: Complete: follow-up continuing
• Health condition(s) or Problem(s) studied: Subarachnoid hemorrhage
• Date of first enrollment: 2024/03/27
• Target sample size: 60
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: We defined delayed cerebral ischemia as a new cerebral infarction occurring 3-18 days after the onset of subarachnoid hemorrhage. The primary endpoint was the ability of RAPID Software's time to maximam analysis values using perfusion CT performed after 8-12 days of onset to predict the development of delayed cerebral ischemia.

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: Exclusions were made for individuals with a fifth grade of the World Federation of Neurosurgical Societies (WFNS) Grade and those who had undergone parent artery occlusion, as their inclusion might compromise the accuracy of cerebral perfusion assessment. Within our institution, all patients afflicted with aSAH underwent CT perfusion imaging between days 8 and 12 following the onset of SAH. Following day 14 post-SAH, either CT or MRI was performed, with the date of SAH onset denoted as day 0. Nevertheless, patients who, for any conceivable reason, did not undergo CT perfusion imaging at any point during their clinical trajectory or did not undergo evaluation for DCI, were subject to exclusion.

Related Information

• Primary Sponsor: Japanese Red Cross Kumamoto Hospital
• Source(s) of Monetary Support: Noshing