NIPH Clinical Trials Search

UMIN ID: UMIN000054121

Registered date:11/04/2024

Computed Tomography Perfusion Tissue Time to Maximum Predict Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage

Basic Information

Recruitment status Complete: follow-up continuing
Health condition(s) or Problem(s) studiedSubarachnoid hemorrhage
Date of first enrollment2024/03/27
Target sample size60
Countries of recruitmentJapan
Study typeObservational


Primary OutcomeWe defined delayed cerebral ischemia as a new cerebral infarction occurring 3-18 days after the onset of subarachnoid hemorrhage. The primary endpoint was the ability of RAPID Software's time to maximam analysis values using perfusion CT performed after 8-12 days of onset to predict the development of delayed cerebral ischemia.
Secondary Outcome

Key inclusion & exclusion criteria

Age minimumNot applicable
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteriaExclusions were made for individuals with a fifth grade of the World Federation of Neurosurgical Societies (WFNS) Grade and those who had undergone parent artery occlusion, as their inclusion might compromise the accuracy of cerebral perfusion assessment. Within our institution, all patients afflicted with aSAH underwent CT perfusion imaging between days 8 and 12 following the onset of SAH. Following day 14 post-SAH, either CT or MRI was performed, with the date of SAH onset denoted as day 0. Nevertheless, patients who, for any conceivable reason, did not undergo CT perfusion imaging at any point during their clinical trajectory or did not undergo evaluation for DCI, were subject to exclusion.

Related Information


public contact
Name Tsuboki Shimpei
Address 929 Higashi-cho, Kamogawa City, Chiba Prefecture, Japan Japan 296-8602
Telephone 04-7092-2211
Affiliation Kameda Medical Center Department of Neuroendovascular surgery
scientific contact
Name Todaka Tatemi
Address 2-1-1 Nagamineminami, Kumamoto City, Kumamoto Prefecture, Japan Japan
Telephone 096-384-2111
Affiliation Japanese Red Cross Kumamoto Hospital Department of Neurosurgery