UMIN ID: UMIN000054119
Registered date:01/05/2024
Predicting neoadjuvant chemotherapy response of muscle-invasive bladder cancer using patient-derived zebrafish xenograft model: multi-institutional prospective study
Basic Information
| Recruitment status | Pending |
|---|---|
| Health condition(s) or Problem(s) studied | Muscle-invasive bladder cancer |
| Date of first enrollment | 2024/05/01 |
| Target sample size | 100 |
| Countries of recruitment | Japan |
| Study type | Observational |
| Intervention(s) |
Outcome(s)
| Primary Outcome | Bladder cancer tissue collected transurethrally before NAC from a patient scheduled to undergo radical cystectomy after neoadjuvant chemotherapy (NAC) with a platinum-based anticancer drug for muscle-invasive bladder cancer. Transplant into zebrafish and evaluate the effectiveness of platinum-based anticancer drugs. The results will be compared with the pathological evaluation of the total cystectomy specimen after NAC, and the concordance rate will be the primary endpoint. |
|---|---|
| Secondary Outcome |
Key inclusion & exclusion criteria
| Age minimum | Not applicable |
|---|---|
| Age maximum | Not applicable |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Patients who are not appropriate to enter the clinical study. |
Related Information
| Primary Sponsor | Mie University Graduate School of Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Grants-in-Aid for Scientific Research |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Yusuke Sugino |
| Address | 2-174 Edobasih Tsu Mie Japan 514-8507 |
| Telephone | 0592315026 |
| tinoue28@med.mie-u.ac.jp | |
| Affiliation | Mie University Graduate School of Medicine Nephro-Urologic Surgery and Andrology |
| scientific contact | |
| Name | TAKAHIRO INOUE |
| Address | 2-174 Edobashi Tsu Mie Japan |
| Telephone | 0592315026 |
| tinoue28@med.mie-u.ac.jp | |
| Affiliation | Mie University Graduate School of Medicine Nephro-Urologic Surgery and Andrology |