The effect of low tidal volume to dynamic arterial elastance in the laparoscopic surgery

UMIN ID: UMIN000054061

Registered date:04/04/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Laparoscopic surgery patient with inserted arterial line during general anesthesia
• Date of first enrollment: 2024/04/05
• Target sample size: 60
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Bolus infusion of 250ml of Ringers solution

Outcome(s)

• Primary Outcome: In laparoscopic surgery patients undergoing general anesthesia with an inserted arterial line, when patients had mean arterial pressure less than 65mmHg and SVV >10%, the Ea dyn at each point will be measured by varying the volume of ventilation from 8 ml/ideal body weight to 6 ml/ideal body weight. The Ea dyn at each point will be measured. Afterwards, 250 ml of Ringer's solution will be administered rapidly, and patients with a 10% or greater increase in mean arterial pressure will be defined as responders.

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: Patients with cardiac ejection fraction less than 40% / patients with atrial fibrillation / patients with severe COPD / patients with right heart failure / highly obese patients (BMI>35) / highly classically thin patients (BMI<15) / supine surgery / side lying surgery / surgery requiring isolated lung ventilation / patients not using laparoscopy.

Related Information

• Primary Sponsor: Jichi medical university
• Source(s) of Monetary Support: None