Time-dependent neural arbitration of stress memories

UMIN ID: UMIN000053938

Registered date:25/03/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Post-traumatic stress disorder
• Date of first enrollment: 2024/03/23
• Target sample size: 20
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Participants are asked to pay attention to audio, still images, and videos, lasting approximately 1 to 5 minutes, played on a monitor or through VR playback devices. During this, we measure intracranial brain waves, skin conductance, and monitor pulse and respiration using wearable devices and sensors. The videos and images may depict mildly stressful scenarios, such as traffic accidents, and may include sudden loud noises. The initial viewing of stress-inducing content occurs on Day 0, followed by a similar viewing on Day 1, and again between Day 3 and Day 5. Measurements of brain waves, skin conductance, pulse, and respiration are taken during these viewings to observe the persistence of stress memory.

Outcome(s)

• Primary Outcome: We analyze the relationship between the duration, frequency, and amplitude of waveforms such as sharp wave ripples (SWRs), and the results of thought content surveys, as well as physiological responses like skin conductance, pulse rate, and respiration, using regression analysis and other statistical methods.

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: 50years-old
• Gender: Male and Female
• Exclude criteria: Patients with significant cognitive impairments. Patients currently undergoing treatment for any psychiatric disorder, those undergoing treatment for or with a history of PTSD, and individuals with a strong aversion to severe accidents such as traffic accidents. Others deemed unsuitable by the principal investigator or co-investigators of the study.

Related Information

• Primary Sponsor: Osaka University
• Source(s) of Monetary Support: Others