Cross-sectional study on metabolic fate determination of brown adipose tissue and its impact on energy homeostasis

UMIN ID: UMIN000053934

Registered date:24/04/2024

Basic Information

• Recruitment status: Pending
• Health condition(s) or Problem(s) studied: Healthy adult volunteers
• Date of first enrollment: 2024/05/01
• Target sample size: 1200
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: Brown adipose tissue activity assessed by FDG-PET/CT and density by NIR-TRS
• Secondary Outcome: Body composition, waist circumference, abdominal fat area, blood parameters including hormones and metabolites, brown fat mass, energy expenditure, respiratory quotient, diet history and nutritional intake, heart rate, blood pressure, adiposity at early lifestages, and epigenetic information in a certain type of cells.

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: <FDG-PET/CT> 1. Individuals with dysfunction of liver, renal, cardiovascular, respiratory, endocrine and nervous systems, or with metabolic disorders, diabetes, consciousness disorders or other disease. 2. Individuals who regularly take medications for diabetes, hyperlipidemia or hypertension. 3. Individuals who smoke over 21 cigarettes a day or consume alcohol more than 30g a day on average. 4. Individuals who are pregnant or breastfeeding 5. Individuals who are considered unsuitable for the study by investigators or medical doctor due to other reasons. <NIR-TRS> 1. Individuals with glucose intolerance, hyperlipidemia, hypertension, hyperuricemia/gout, coronary artery disease, cerebral infarction, non-alcoholic fatty liver disease, menstrual disorder, sleep apnea syndrome, motor system disease, obesity-related kidney disease or cardiovascular risk. 2. Individuals with BMI 30 kg/m^2 or more. 3. Individuals with visceral fat area over 100cm^2. 4. Individuals who are considered unsuitable for the study by investigators or medical doctor due to other reasons. <Epigenome> 1. Individuals with dysfunction of liver, renal, cardiovascular, respiratory, endocrine and nervous systems, or with metabolic disorders, diabetes, consciousness disorders or other disease. 2. Individuals who regularly take medications for diabetes, hyperlipidemia or hypertension. 3. Individuals who smoke over 21 cigarettes a day or consume alcohol more than 30g a day on average. 4. Female. 5. Individuals who are considered unsuitable for the study by the investigators due to other reasons.

Related Information

• Primary Sponsor: Tohoku University
• Secondary Sponsor: The University of Tokyo Tenshi College Tokyo Medical University LSI Sapporo Clinic
• Source(s) of Monetary Support: Japan Agency for Medical Research and Development,Japan Science and Technology Agency Japan Society for the Promotion of Science