Investigation of differences in the anesthetic action of the intravenous anesthetic remimazolam according to gender.

UMIN ID: UMIN000051489

Registered date:30/06/2023

Basic Information

• Recruitment status: Recruiting
• Health condition(s) or Problem(s) studied: Dental or oral surgical disease
• Date of first enrollment: 2023/06/30
• Target sample size: 50
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: Time from discontinuation of remimazolam to tracheal extubation
• Secondary Outcome: 1. Patient Characteristics (age, weight, height, BMI, sex, medical history, medicine, clinical examination) 2. Surgical information (procedure, operation time, anesthesia time) 3. Blood concentration of remimazolam and its metabolite CNS7054 at discontinuation of remimazolam and tracheal extubation or administration of flumazenil 4. BIS values at discontinuation of remimazolam and tracheal extubation or administration of flumazenil 5. Remimazolaml amount and average infusion rate of remimazolam 6. Remifentanil amount and average infusion rate of remifentanil 7. BIS values at pre-anesthesia, loss of consciousness, and during anesthesia 8. Time from start of remimazolam to loss of consciousness 9. Number of bolus dose of remimazolam

Key inclusion & exclusion criteria

• Age minimum: 18years-old
• Age maximum: 50years-old
• Gender: Male and Female
• Exclude criteria: 1. Patients with contraindications to remimazolam, remifentanil, or rocuronium 2. Patients who require preanesthetic medication 3. Patients who are deemed inappropriate for participation in the study by the principal investigator or study investigator.

Related Information

• Primary Sponsor: Okayama University
• Source(s) of Monetary Support: Okayama University