UMIN ID: UMIN000050637
Registered date:20/03/2023
Comparative potentiating effects of remimazolam, propofol and sevoflurane on rocuronium-induced neuromuscular block: a randomised controlled trial
Basic Information
| Recruitment status | Recruiting |
|---|---|
| Health condition(s) or Problem(s) studied | Patients undergoing general anesthesia |
| Date of first enrollment | 2023/03/21 |
| Target sample size | 99 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | For general anaesthetics, the remimazolam is selected by the envelope method. Blood samples are taken at the time of appearance of PTC and TOF to determine the blood concentration of rocuronium. For general anaesthetics, the sevoflurane is selected by the envelope method. Blood samples are taken at the time of appearance of PTC and TOF to determine the blood concentration of rocuronium. For general anaesthetics, the propofol is selected by the envelope method. Blood samples are taken at the time of appearance of PTC and TOF to determine the blood concentration of rocuronium. |
Outcome(s)
| Primary Outcome | The time from administration of rocuronium to first appearance of PTC response |
|---|---|
| Secondary Outcome | The time from administration of rocuronium to TOFC0 (onset time), time from administration of rocuronium to first reappearance of TOFC1 (time to TOFC1), time from administration of rocuronium to first reappearance of TOFC2 (time to TOFC2), time from administration of sugammadex to TOF ratio 90% or higher, and blood concentration of rocuronium in the appearance of PTC and TOF. |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 65years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Patients with American Society of Anesthesiologists physical status classification 4 or more, patients with a history of allergic reaction to NMBAs, patients with hepatic disease, patients with neuromuscular disease, and patients who were receiving medication known to interfere with neuromuscular function. |
Related Information
| Primary Sponsor | Nihon University School of Medicine |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Nihon University School of Medicine |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Hanae Sato |
| Address | 30-1, Oyaguchi Kamicho, Itabashi-Ku, Tokyo, Japan 1738610 |
| Telephone | +81-3-3972-8111 |
| nakamura.hanae@nihon-u.ac.jp | |
| Affiliation | Nihon University School of Medicine Department of Anesthesiology |
| scientific contact | |
| Name | Hanae Sato |
| Address | 30-1, Oyaguchi Kamicho, Itabashi-Ku, Tokyo, Japan |
| Telephone | +81-3-3972-8111 |
| nakamura.hanae@nihon-u.ac.jp | |
| Affiliation | Nihon University School of Medicine Department of Anesthesiology |