UMIN ID: UMIN000049707
Registered date:06/12/2022
Comparison of postoperative nausea and vomiting between general anesthesia with remimazolam and general anesthesia with propofol: A randomized non-inferiority trial.
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | Patients undergoing surgery under general anesthesia who do not receive postoperative opioids by epidural analgesia nor intravenous PCA. |
| Date of first enrollment | 2023/05/08 |
| Target sample size | 110 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | remimazolam-based total intravenous anesthesia propofol-based total intravenous anesthesia |
Outcome(s)
| Primary Outcome | the incidence of postoperative nausea and vomiting for 3 hours and 24 hours after the surgery. |
|---|---|
| Secondary Outcome | rescue antiemetic use, severity of nausea ,timing of onset of PONV |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 80years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | Patients with severe cardiac, renal, or hepatic dysfunction, severe anemia, and allergies to remimazolam or propofol. |
Related Information
| Primary Sponsor | Kobe city medical center general hospital |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | Kobe city medical center general hospital |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Hiroshi Yamashita |
| Address | Kobe city Chuouku Minatojimaminamichou2-1-1 Japan 6500047 |
| Telephone | 0783024321 |
| cantateveritas@kcho.jp | |
| Affiliation | Kobe city medical center general hospital department of anesthesiology |
| scientific contact | |
| Name | Hiroshi Yamashita |
| Address | Kobe city Chuouku Minatojimaminamichou2-1-1 Japan |
| Telephone | 0783024321 |
| cantateveritas@kcho.jp | |
| Affiliation | Kobe city medical center general hospital department of anesthesiology |