NIPH Clinical Trials Search

JAPANESE
国立保健医療科学院
UMIN ID: UMIN000047758

Registered date:16/05/2022

Study on biomarkers for the effect and safety of the treatment with Atezolizumab + Bevacizumab for liver cancer

Basic Information

Recruitment status Recruiting
Health condition(s) or Problem(s) studiedunresectable advanced hepatocellular carcinoma
Date of first enrollment2022/05/06
Target sample size91
Countries of recruitmentJapan
Study typeObservational
Intervention(s)

Outcome(s)

Primary OutcomeInvestigating the biomarkers, including cytokine and chemokine at pretreatment, 1,3,6 week after treatment, on adverse events, including immune-related liver injury
Secondary OutcomeInvestigating the biomarkers, including cytokine and chemokine at pretreatment, 1,3,6 week after treatment, on the therapeutic effects and prognosis

Key inclusion & exclusion criteria

Age minimum20years-old
Age maximumNot applicable
GenderMale and Female
Include criteria
Exclude criteriaPatients who wish to be excluded from the study. Patients who are pregnant, or lactating, may become pregnant, intend to become pregnant, or who wish to have a baby. Patients with the following serious complications: 1. Cardiovascular abnormalities such as heart failure, angina pectoris, or arrhythmia are difficult to control even after treatment. 2. Myocardial infarction within 6 months of onset 3. Renal failure 4. Active infectious disease except for viral hepatitis 5. Active gastrointestinal bleeding 6. Other active cancer requiring treatment 7. Hepatic encephalopathy or severe mental disorder 8. Severe drug allergy 9. Serious autoimmune disease. Other conditions that the physician deems inappropriate for the safe conduct of this study.

Related Information

Contact

public contact
Name Takanori Ito
Address 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8560, Japan. Japan 466-8560
Telephone 0527442169
E-mail tahkun56@med.nagoya-u.ac.jp
Affiliation Nagoya University Hospital Gastroenterology and Hepatology
scientific contact
Name Masatoshi Ishigami
Address 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8560, Japan. Japan
Telephone 0527442169
E-mail masaishi@med.nagoya-u.ac.jp
Affiliation Nagoya University Graduate School of Medicine Gastroenterology and Hepatology