Comparison of remimazolam and propofol anesthesia for interventional neuroradiology

UMIN ID: UMIN000047384

Registered date:04/04/2022

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: IV general anesthesia for interventional neuroradiology
• Date of first enrollment: 2022/05/12
• Target sample size: 76
• Countries of recruitment: Asia(except Japan)
• Study type: Interventional

Intervention(s)

In the intervention group, general anesthesia is performed using intravenous remimazolam infusion.
In the intervention group, general anesthesia is performed using intravenous propofol infusion.

Outcome(s)

• Primary Outcome: - Total phenylephrine dose required to restore blood pressure during hypotensive events during the procedure
• Secondary Outcome: - The number of hypotension events - Intraoperative remifentanil dose - Time from the end of hemostatic compression to return of spontaneous breathing, time to eye opening, time to extubation, and time to orientation recovery - Time from the end of hemostatic compression to BIS 75, time from flumazenil injection to extubation, time from flumazenil injection to return of orientation (only in remimazolam group) - Intraoperative vital signs

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: 65years-old
• Gender: Male and Female
• Exclude criteria: - A ruptured aneurysm - Multiple aneurysms - History of neuromuscular/cognitive/psychiatric disease (on medication) - Preexisting renal or hepatic dysfunction - Glaucoma

Related Information

• Primary Sponsor: Seoul National University Bundang Hospital
• Source(s) of Monetary Support: Seoul National University Bundang Hospital