Whether the lactate transport carrier is a biomarker for type 2 diabetes?

UMIN ID: UMIN000035924

Registered date:18/02/2019

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Type2 diabetes
• Date of first enrollment: 2014/05/08
• Target sample size: 100
• Countries of recruitment: Japan
• Study type: Observational

Outcome(s)

• Primary Outcome: Correlation between plasma lactate, alanine and known diabetes marker (fasting blood glucose, HbA1c, insulin secretion ability etc.).
• Secondary Outcome: 1. Correlation between plasma lactate, alanine and clinical information (age, sex, body weight, BMI, renal function, TG, LDL, HDL etc.). 2. Differences in the frequency of polymorphisms of diabetes-related genes in MCT 1, 4, 11 and the relationship between lactate and alanine and known diabetes markers.

Key inclusion & exclusion criteria

• Age minimum: 20years-old
• Age maximum: Not applicable
• Gender: Male and Female
• Exclude criteria: (1) Patients diagnosed as type1 diabetes, or a pancreas-associated autoantibody such as glutamic acid decarboxylase antibody was positive. (2) Patients diagnosed as respiratory failure or serious liver failure. (3) Patients who were judged inappropriate as the subject by the research director.

Related Information

• Primary Sponsor: Hokkaido University Hospital, Department of Pharmacy
• Source(s) of Monetary Support: A Grant-in-Aid for Scientific Research (JSPS KAKENHI Grant)