Intergenerational neuroimaging study of the human brain circuitry in major psychiatric disorders

UMIN ID: UMIN000025245

Registered date:13/12/2016

Basic Information

• Recruitment status: Open public recruiting
• Health condition(s) or Problem(s) studied: Major psychiatric disorder (Schizophrenia, Bipolar disorder, and Depression)
• Date of first enrollment: 2017/01/01
• Target sample size: 320
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

Brain MRI/Parent diagnosed with major psychiatric disorder and healthy offspring pair
Brain MRI/Healthy parent-offspring pair

Outcome(s)

• Primary Outcome: The brain regions where specific parent-offspring pairs (e,g, depressed mother and high-risk daughter dyads) consistently show greater associations compared to other parent and offspring dyads (e.g, depressed father and high-risk son dyads).

Key inclusion & exclusion criteria

• Age minimum: 16years-old
• Age maximum: Not applicable
• Gender: Male and Female

Include criteria

･Schizophrenia, bipolar disorder, and depression diagnosed based on DSM-5 and their healthy biological offsprings
･Healthy parent and their biological offspring pairs
･Healthy controls scored more than 24 points in MMSE or 70 in JART
･Reliable informed consent could be obtained from the patient and or his her relatives

Exclude criteria

･Participants were required to have had no lifetime history of any psychiatric disorders, or drug or alcohol misuse, as well as no neurological disorder
･None of the participants reported unstable medical condition and history of significant head trauma.

Related Information

• Primary Sponsor: Keio University School of Medicine
• Source(s) of Monetary Support: Ministry of education