Minimal dose oral cephalosporin regimen(MDC regimen), a new empiric therapy for the treatment of uncomplicated cystitis in women during the era of an increasing prevalence of drug-resistant pathogens.

UMIN ID: UMIN000018071

Registered date:10/07/2015

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: Acute uncomplicated cystitis in wpmen.
• Date of first enrollment: 2005/04/01
• Target sample size: 100
• Countries of recruitment: Japan
• Study type: Interventional
• Intervention(s): Prescriibe 40mg cefaclor/day for a week that is divided in two doses onto empty stomch.

Outcome(s)

• Primary Outcome: Promptly getting asymptomatic and pyuria is cleared, and pathogens are eradicated from urine in a week, and no recurrence during the long term preventive treatment in the patients having suffered frequent recurrence.
• Secondary Outcome: No association of untoward reaction such as gastric symptom and anaphylactic reaction. Further, no recurrence with drug resistant pathogen during the long term treatment for prevention of frequent recurrence.

Key inclusion & exclusion criteria

• Age minimum: Not applicable
• Age maximum: Not applicable
• Gender: Female
• Exclude criteria: Patients who have strucural of functional abnormality in the urinary tract.

Related Information

• Primary Sponsor: Yorio Naide
• Secondary Sponsor: Department of Infectious Diseases, School of Medicine, Keio University Department of Infectious Diseases, School of Medicine, Kitasato University
• Source(s) of Monetary Support: Yorio Naide,None