UMIN ID: UMIN000015997
Registered date:20/12/2014
WT1 peptide-based cancer vaccine for long-term maintenance of anti-tumor immunity
Basic Information
| Recruitment status | Complete: follow-up complete |
|---|---|
| Health condition(s) or Problem(s) studied | solid tumor, malignant lymphoma, acute leukemia |
| Date of first enrollment | 2014/12/24 |
| Target sample size | 56 |
| Countries of recruitment | Japan |
| Study type | Interventional |
| Intervention(s) | Administration of WT1 peptide vaccine |
Outcome(s)
| Primary Outcome | DTH to WT1 peptide Frequency of WT1 specific CTLs |
|---|---|
| Secondary Outcome | Safety 1 Numbers and frequencies of adverse effects defined in NCI-CTCAE v4.0 2 Frequencies of hematological- and non-hematological adverse effects which result in suspension or withdrawal of WT1 peptide vaccine Anti-tumor effects Anti-tumor effects are evaluated at 3-6 months intervals by the method described elsewhere. |
Key inclusion & exclusion criteria
| Age minimum | 20years-old |
|---|---|
| Age maximum | 85years-old |
| Gender | Male and Female |
| Include criteria | |
| Exclude criteria | 1. having severe infectious disease 2. having developed adverse effects (grade >=4) in the prior WT1 peptide vaccine trial 3. having severe complications 4. having severe mental disorders |
Related Information
| Primary Sponsor | Osaka University Graduate Shool of Medicine, Functional Diagnostic Science |
|---|---|
| Secondary Sponsor | |
| Source(s) of Monetary Support | MEXT(Japan),Non-pharmaceutical companies |
| Secondary ID(s) |
Contact
| public contact | |
| Name | Yusuke Oji |
| Address | 1-7 Yamada-oka Suita city Osaka, Japan Japan |
| Telephone | 06-6879-2597 |
| oji@sahs.med.osaka-u.ac.jp | |
| Affiliation | Osaka University Graduate School of Medicine Cancer Stem Cell Biology |
| scientific contact | |
| Name | Haruo Sugiyama |
| Address | 1-7 Yamada-oka Suita city Osaka, Japan Japan |
| Telephone | 06-6879-2597 |
| sugiyama@sahs.med.osaka-u.ac.jp | |
| Affiliation | Osaka University Graduate School of Medicine Dept Functional Diagnostic Science |