Visualization and Qualification of Abnormal Semantic Representation in Schizophrenia

UMIN ID: UMIN000014048

Registered date:23/05/2014

Basic Information

• Recruitment status: Complete: follow-up complete
• Health condition(s) or Problem(s) studied: schizophrenia
• Date of first enrollment: 2014/07/01
• Target sample size: 40
• Countries of recruitment: Japan
• Study type: Interventional

Intervention(s)

We perform functional MRI scanning for healthy group using various movies or psychological tasks as visual stimuli. We investigate its voxelwise relationships with conceptual thesaurus made from the stimuli.
We perform functional MRI scanning for schizophrenia group using various movies or psychological tasks as visual stimuli. We investigate its voxelwise relationships with conceptual thesaurus made from the stimuli. We evaluate how they change chronologically (about 3-12 months) by clinical therapeutic intervention.

Outcome(s)

• Primary Outcome: The primary outcome is to evaluate abnormal visual information processing in schizophrenia by comparing cortical activation and semantic representation maps between groups, and investigate the symptomatologic significance using psychological measures.
• Secondary Outcome: The key secondary outcome is to examine the treatment effects by comparing how much the treatments affect above-mentioned parameters.

Key inclusion & exclusion criteria

• Age minimum: 16years-old
• Age maximum: 60years-old
• Gender: Male and Female
• Exclude criteria: a person under sixteen or from sixty years and up, a person with nervous disease or disease which could affect nervous system regeneration, and a person who is not sufficiently able to agree with due to the condition of disease

Related Information

• Primary Sponsor: Kyoto University Graduate School of Medicine
• Source(s) of Monetary Support: Strategic Research Program for Brain Science